TLR1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	Dot, FC, IHC, WB
Recommend Dilution	Flow Cytometry: 2-4 ug/ 1x10-6 cells, Western Blot: 1-3 ug/ml, Immunohistochemistry-Paraffin: 10 ug/ml, Flow (Cell Surface), Flow (Intracellular): 0.5-1 ug/1 million cells, Immunohistochemistry, Dot Blot
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	This antibody was developed against a KLH-conjugated synthetic peptide corresponding to a sequence within amino acids 400-450 of human TLR1.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	toll like receptor 1
Database Link	NP_003254 Entrez Gene 21897 MouseEntrez Gene 305354 RatEntrez Gene 7096 Human UniProt ID Q15399
Background	The Toll-like receptor (TLR) family in mammals are comprised of a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an IL-1 receptor motif in the cytoplasmic domain. The TLRs could constitute an important and unrecognized component of innate immunity in humans. In mice, TLR1 interacts with TLR2 and coexpression of TLR1 and TLR2 enhance the NF-kappaB activation in response to a synthetic lipopeptide. They recognize the lipid configuration of the native mycobacterial lipoprotein as well as several triacylated lipopeptides.
Synonyms	CD281; rsc786; TIL; TIL. LPRS5
Note	Flow (Cell Surface): 0.5-1 ug/10^6 cells, or see Wong et al, 2007 Flow (Intracellular): 0.5-1 ug/10^6 cells
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Toll-like receptor signaling pathway

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