Fos B (FOSB) Mouse Monoclonal Antibody [Clone ID: 83B1138]

Specifications

Product Data
Clone Name	83B1138
Applications	WB
Recommend Dilution	Western Blot: 2 ug/mL
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	This antibody was generated by immunizing mice with a synthetic peptide corresponding to amino acids 2-15 of human FosB.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	FosB proto-oncogene, AP-1 transcription factor subunit
Database Link	NP_006723 Entrez Gene 2354 Human UniProt ID P53539
Background	The v-Fos oncogene was initially identified as the transforming gene of two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a 62 kDa nuclear phosphoprotein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo and heterodimers, which bind to specific DNA TPA response elements (TREs), c-Fos proteins are only active as heterodimers with members of the Jun gene family. Murine FosB encodes a nuclear protein of 338 amino acids which has 70% homology with c-Fos, exhibits similar kinetics of expression as c-Fos and forms heterodimers with both c-Jun and Jun B which bind to TRE DNA response elements. Functional homologs of c-Fos and FosB include Fra-1 and Fra-2 genes.
Synonyms	AP-1; G0S3; GOS3; GOSB
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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