DR4 (TNFRSF10A) Mouse Monoclonal Antibody [Clone ID: 32A242]

Specifications

Product Data
Clone Name	32A242
Applications	ICC/IF, Immunoblotting, WB
Recommend Dilution	Western Blot: 1 - 3 ug/ml, Immunocytochemistry/ Immunofluorescence, Immunoblotting
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	This monoclonal antibody was raised against a peptide corresponding to amino acid 2 to 21 of human DR4.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	tumor necrosis factor receptor superfamily member 10a
Database Link	NP_003835 Entrez Gene 8797 Human UniProt ID O00220
Background	Cells undergo programmed cell death (Apoptosis) in response to various stimuli. Apoptosis is essential for morphogenesis, tissue homeostasis, and host defense. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR4 (for death receptor 4). The ligand for this novel death receptor has been identified and termed TRAIL, which is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAIL-R1). DR4 is expressed in most human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF-kB activation in many tissues and cells.
Synonyms	APO2; CD261; DR4; TRAILR-1; TRAILR1
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity

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