SMN1 Mouse Monoclonal Antibody [Clone ID: 2B1]

Specifications

Product Data
Clone Name	2B1
Applications	ELISA, FC, ICC/IF, IHC, IP, WB
Recommend Dilution	Immunohistochemistry, Immunocytochemistry/ Immunofluorescence: 1:250, Immunoprecipitation: 1:10-1:500, Western Blot: 2 ug/ml, Immunohistochemistry-Paraffin: 1:200, ELISA, Flow Cytometry
Reactivity	Human, Mouse, Rat, Primate, Xenopus
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant His6-tagged human SMN protein. [Swiss-Prot# Q16637]
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	survival of motor neuron 1, telomeric
Database Link	NP_075012 Entrez Gene 20595 MouseEntrez Gene 64301 RatEntrez Gene 6606 Human UniProt ID Q16637
Background	Spinal muscular atrophy (SMA) is a common fatal autosomal recessive disorder characterized by the degeneration of motor neurons and muscular atrophy. A gene called Survival of Motor Neurons (SMN) has been identified as the determining gene in SMA and is deleted or mutated in greater than 98% of SMA patients. The SMN protein localizes to both the cytoplasm and the nucleus. In the nucleus, SMN has been found to localize in a nuclear structure termed gems for Gemini of coiled bodies, which contain high levels of small ribonucleoproteins (snRNPs). SMN forms complexes with proteins including SIP1, Gemin 2-7 and several others known to be involved in the biogenesis of snRNPs. SMN antibodies may serve as a useful research tool to study SMN complexes and gems, and their role in pre-RNA processing and RNA metabolism.
Synonyms	BCD541; GEMIN1; SMA; SMA1; SMA2; SMA3; SMA4; SMA@; SMN; SMNT; T-BCD541; TDRD16A
Note	This SMN Antibody (2B1) is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry on paraffin-embedded sections, Flow Cytometry, Immunoprecipitation and Western blot where a band can be seen at ~ 35 kDa. Use in ELISA reported in scientific literature (PMID 23973875)
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency

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