STAT6 Rabbit Polyclonal Antibody
CAT#: TA333295
Phospho-STAT6-Y641 Rabbit Polyclonal Antibody
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Specifications
Product Data | |
Applications | IHC, WB |
Recommend Dilution | WB 1:500-1:2000 |
Reactivity | Human, Mouse, Rat |
Modifications | Phospho-specific |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | A phospho specific peptide corresponding to residues surrounding Y641 of human STAT6 |
Formulation | Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Concentration | lot specific |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | 847 |
Gene Name | signal transducer and activator of transcription 6 |
Database Link | |
Background | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants. |
Synonyms | D12S1644; IL-4-STAT; STAT6B; STAT6C |
Reference Data | |
Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway, Stem cell relevant signaling - JAK/STAT signaling pathway, Transcription Factors |
Protein Pathways | Jak-STAT signaling pathway |
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