p27 KIP 1 (CDKN1B) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, WB
Recommend Dilution	WB 1:200 - 1:500;IF 1:20 - 1:50
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human CDKN1B
Formulation	PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	27 kDa
Gene Name	cyclin-dependent kinase inhibitor 1B
Database Link	NP_004055 Entrez Gene 12576 MouseEntrez Gene 1027 Human UniProt ID P46527
Background	CDKN1B Kip1 is a member of the Cip/Kip family of cyclin-dependent kinase inhibitors. Like its relatives, p57 Kip2 and p21 Waf1/Cip1, the ability to enforce the G1 restriction point is derived from its inhibitory binding to CDK2/cyclin E and other CDK/cyclin complexes. Expression levels of CDKN1B are upregulated in quiescent cells and in cells treated with cAMP or other negative cell cycle regulators. Downregulation of CDKN1B can be induced by treatment with interleukin 2 or other mitogens; this involves phosphorylation of CDKN1B and its degradation by the ubiquitin-proteasome pathway (1-4).
Synonyms	CDKN4; KIP1; MEN1B; MEN4; P27KIP1
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Cell cycle, Chronic myeloid leukemia, ErbB signaling pathway, Pathways in cancer, Prostate cancer, Small cell lung cancer

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