Kcnab1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:200-1:2000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide (C)TPQHHISLKESTAK, corresponding to amino acid residues 54-67 of rat KVÃ?1. N-terminus.
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized antigen.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	potassium voltage-gated channel subfamily A member regulatory beta subunit 1
Database Link	NP_058999 Entrez Gene 7881 HumanEntrez Gene 16497 MouseEntrez Gene 29737 Rat UniProt ID P63144
Background	Voltage-gated K+ channels represent a structurally and functionally diverse group of membrane proteins. These channels establish the resting membrane potential and modulate the frequency and duration of action potentials in nerve and muscle1. The duration of the open states of K+ channels is determined by the rates of deactivation and inactivation. KV channels are hetero-oligomeric complexes consisting of two different types of subunits: membrane-bound, pore-forming a subunits and the smaller Ã? subunits. The Ã? subunits appear to be peripheral proteins tightly associated with the cytoplasmic side of the a subunits. The inactivation gate can be formed by an N-terminal segment of an auxiliary Ã?-subunit, as in the complex of KVÃ?1 and KVa family channels3. There are three mammalian KVÃ? genes: KVÃ?1, KVÃ?2 and KVÃ?3. Additional variability in the KVÃ?1 family results from alternative splicing in the amino terminal region, thus yielding the KVÃ?1.1, KVÃ?1.2, and KVÃ?1.3 subunits.
Synonyms	AKR6A3; hKvb3; hKvBeta3; KCNA1B; KV-BETA-1; Kvb1.3
Reference Data

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