Nlgn2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivity	Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide (C)DLGPRAYDRFPGDS, corresponding to amino acid residues 657-670 of rat Neuroligin 2 . Extracellular, N-terminus.
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized antigen.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	neuroligin 2
Database Link	NP_446444 Entrez Gene 216856 MouseEntrez Gene 117096 Rat UniProt ID Q62888
Background	Neuroligins (NLGNs) are family of postsynaptic cell adhesion molecules that play an important role in synaptic development and function. Four genes encode for the different members of the neuroligin family in mammals: NLGN 1-4, which are differentially enriched in postsynaptic specializations of synapses. Neuroligin 2 (NLGN2) is expressed in neurons in the brain and also in pancreatic Ã? cells where it facilitates insulin secretion.Synaptic maturation is promoted by the binding of Neuroligin 2 with presynaptic Neurexins, and these interactions are restricted to particular combinations of isoforms of the binding partners. NLGN2 plays a role in synapse function and synaptic signal transmission, especially via ?-aminobutyric acid receptors (GABA(A) receptors). NLGN2 modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Recent studied identified a loss-of-function mutation of NLGN2 in schizophrenia patients, suggesting an indispensable role of NLGN2 in regulating GABAergic functions5.
Synonyms	KIAA1366
Note	This antibody was tested in live cell imaging. Please see IF/ICC data for detail.
Reference Data

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