Slc6a11 Rabbit Polyclonal Antibody
CAT#: TA328858
Rabbit Polyclonal Anti-GABA Transporter 3 (GAT-3)
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CNY 11,000.00
货期*
7周
规格
经常一起买 (1)
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Specifications
Product Data | |
Applications | WB |
Recommend Dilution | WB: 1:200-1:2000 |
Reactivity | Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Peptide (C)REARDKAVHERGH, corresponding to amino acid residues 35- 47 of rat GABA Transporter 3. Intracellular, N-terminus. |
Formulation | Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3. |
Reconstitution Method | Add 50 ul double distilled water (DDW) to the lyophilized powder. |
Purification | Affinity purified on immobilized antigen. |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | solute carrier family 6 member 11 |
Database Link | |
Background | Gamma-aminobutiric acid (GABA) is the major inhibitory neurotransmitter in the mammalian central nervous system. Transmission via GABA can be halted by its reuptake through GABA transporters (GATs). These membrane proteins belong to the super family of slc6 genes which encode transporters responsible for the uptake of dopamine, serotonin, norepinephrine, glycine and GABA in a Na+-dependent manner.To date, four GATs have been identified: GAT-1, GAT-2, GAT-3 and BGT-1. Like all members of the slc6 family, they have twelve transmembrane domains and short intracellular N- and C-termini. GATs couple the transport of one GABA molecule to two Na+ ions and one Cl- ion.GAT-3 is highly expressed in the brain and is linked to epilepsy. |
Synonyms | GABT3; GAT-3; GAT3 |
Reference Data |
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