Phospholamban (PLN) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:1000
Reactivity	Human, Mouse, Rat, Bovine, Pig, Rabbit
Host	Rabbit
Clonality	Polyclonal
Immunogen	This PLN antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1-22 amino acids from the N-terminal region of human PLN.
Formulation	PBS with 0.09% (W/V) sodium azide
Concentration	lot specific
Purification	This antibody is purified through a protein A column, followed by peptide affinity purification.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	phospholamban
Database Link	NP_002658 Entrez Gene 18821 MouseEntrez Gene 64672 RatEntrez Gene 5350 Human UniProt ID P26678
Background	Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2 Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.
Synonyms	CMD1P; CMH18; PLB
Reference Data
Protein Families	Transmembrane
Protein Pathways	Calcium signaling pathway, Dilated cardiomyopathy

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