Rorc Mouse Monoclonal Antibody [Clone ID: 4F3-3C8-2B7]

Specifications

Product Data
Clone Name	4F3-3C8-2B7
Applications	WB
Recommend Dilution	WB
Reactivity	Human, Mouse (weak)
Host	Mouse
Clonality	Monoclonal
Immunogen	Human ROR?-GST recombinant protein
Formulation	Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Concentration	lot specific
Purification	The antibody was purified by affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	RAR-related orphan receptor gamma
Database Link	NP_035411 Entrez Gene 6097 HumanEntrez Gene 19885 Mouse UniProt ID P51450
Background	RORγ (Retinoid-related orphan receptor gamma) belongs to the nuclear hormone receptor family, NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. RORγ has two isoforms: γ1 and γ2 (also referred to as RORγt). The RORγt differs from the RORγ1 isoform in that it lacks the amino terminus of RORγ1. RORγ1 contains 516 amino acids and RORγt contains 495 amino acids. RORγ1 has a molecular weight of approximately 58 kD. RORγ1 is highly expressed in thymus, kidney, liver, muscle, and brown fat but not in white fat tissue. RORγt is specifically expressed in only two cell populations, DP thymocytes and lymphoid tissue inducers (LTi). RORγ plays a critical role in control apoptosis during thymopoiesis and T cell homeostasis. RORγ is to regulate TCRα repertoire by virtue of its positive regulatory role on Bcl-x expression. RORγ is essential for lymph nodes and Peyers patches development.
Synonyms	MGC129539; NR1F3; RORG; RZR-GAMMA; RZRG; TOR
Reference Data

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