KAP1 (TRIM28) Mouse Monoclonal Antibody [Clone ID: 20A1]

Specifications

Product Data
Clone Name	20A1
Applications	IF, WB
Recommend Dilution	WB, IF, ChIP
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Not provided
Formulation	This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide at 0.5 mg/ml.
Concentration	lot specific
Purification	The antibody was purified by affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	110 kD
Gene Name	tripartite motif containing 28
Database Link	NP_005753 Entrez Gene 10155 Human UniProt ID Q13263
Background	TIFβ (transcription intermediary factor 1-beta) is an 88 kD member of the tripartite motif family. This protein contains three zinc binding domains, a RING domain, a B-box type 1 and type 2 domain, and a coiled-coil region. TIFβ is found in the nucleus and associates with specific chromatin regions. This protein forms a complex with KRAB-domain transcription factors and recruits setdbl to histone 3 to increase KRAB-mediated transcriptional repression. TIF1β has been reported to interact with setdbl and cbx3 proteins. Studies using knockout mice reveal the important function of TIF1β in regulating genomic imprinting, T cell activation, and T cell tolerance.
Synonyms	KAP1; PPP1R157; RNF96; TF1B; TIF1B
Reference Data
Protein Families	Protein Kinase, Stem cell - Pluripotency, Transcription Factors

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