Cathelicidin (CAMP) Mouse Monoclonal Antibody [Clone ID: H7]

Specifications

Product Data
Clone Name	H7
Applications	WB
Recommend Dilution	WB, IF, IP, Fc
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Partially purified human neutrophil membrane proteins, with epitope mapping to amino acids 115-121
Formulation	This antibody is provided in phosphate-buffered solution, pH 7.2, 0.09% NaN3.
Concentration	lot specific
Purification	The antibody was purified by affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	19.3 kD
Gene Name	cathelicidin antimicrobial peptide
Database Link	NP_004336 Entrez Gene 820 Human UniProt ID P49913
Background	Antimicrobial peptides (AMP) are effector molecules of the innate immune system with direct antimicrobioal and immunomodulatory effects. AMP are produced by epithelial and professional host defense cells such as macrophages or neutrophils. AMP directly inactivate microorganisms and, in addition, have diverse activities on various cell types. In mammals, peptides of the defensin and the cathelicidin families are found. hCAP-18 is the only cathelicidin present in humans. hCAP-18 is a 170 amino acid cathelicidin anti-microbial precursor protein that is proteolytically processed to yield the antibacterial peptide LL-37. The precursor hCAP-18 is found in the specific granules of neutrophils and is expressed in many immune and epithelial cells. Cathelicidin has an established role in host defense. In addition to their direct antimicrobial function, cathelicidin peptides are involved in the modulation of repair and tissue homeostasis, epithelial wound healing, chemoattraction of immune cells, and release of inflammatory mediators from epithelial cells. Recent studies also found that LL-37 significantly regulates endocytic capacity, modifies expression of phagocytic receptors, increases secretion of Th1-inducing cytokines of dendritic cells (DC) generated from blood monocytes, and modulates the response of monocytes and DC to toll like receptor (TLR)–ligands. Moreover LL-37 also modulates the response of neutrophils to bacterial activation.
Synonyms	CAP-18; CAP18; CRAMP; FALL-39; FALL39; HSD26; LL37
Reference Data
Protein Families	Secreted Protein, Transmembrane

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