Thrombomodulin (THBD) Mouse Monoclonal Antibody [Clone ID: 1009]

Specifications

Product Data
Clone Name	1009
Applications	IHC
Recommend Dilution	IHC: 1:25 - 1:100
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Formulation	This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	thrombomodulin
Database Link	NP_000352 Entrez Gene 7056 Human UniProt ID P07204
Synonyms	AHUS6; BDCA3; CD141; THPH12; THRM; TM
Note	Thrombomodulin (TM) is a transmembrane glycoprotein composed of 575 amino acids (molecular weight 75 kD) with natural anticoagulant properties. It is normally expressed by a restricted number of cells such as endothelial and mesothelial cells. In addition, synovial lining and syncytiotrophoblasts of human placenta also express TM. Several immunohistochemical endothelial markers are currently available and anti-thrombomodulin serves as another such marker, staining blood and lymphatic channels consistently. Anti-TM has demonstrated positivity in 100% of benign vascular tumors (pyogenic granuloma and hemangioma) and 94% of malignant vascular tumors (Kaposi’s sarcoma, angiosarcoma, and epithelioid hemangioendothelioma). Hence, anti-TM serves as a sensitive marker for lymphatic endothelial cells and their tumors. There has also been recent interest in the use of anti-TM as an immunohistochemical marker for mesothelial cells and malignant mesotheliomas. Anti-TM is immunoexpressed in a variety of other tumors including squamous cell carcinomas of the lung, synovial sarcoma, transitional cell carcinoma, renal cell carcinomas, and thymomas.
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Complement and coagulation cascades

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