Gastrin (GAST) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 1:100 - 1:500
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Formulation	This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	gastrin
Database Link	NP_000796 Entrez Gene 2520 Human UniProt ID P01350
Synonyms	GAS
Note	Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms: G34 and G17. They activate two different receptors: the CCK-1 receptor, which has low affinity for gastrin but high affinity for the related hormone cholecystokinin (CCK), and the CCK-2 receptor, which has high affinity for both gastrin and CCK and mediates the acid-secretory as well as the proliferative effects of gastrin. More recently, gastrin has been suggested to induce leukocyte-endothelial cell interactions and to have a pro-inflammatory effect.Anti-gastrin stains G-cells of human antral/pyloric mucosa and cells producing gastrin or a structural gastrin analog as is seen in stomach; no staining of other cells or tissue types has been observed. This antibody may react with sulfated and non-sulfated forms of gastrin.
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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