IKK alpha (CHUK) Rabbit Polyclonal Antibody

CAT#: TA327250

Rabbit anti-CHUK Polyclonal Antibody



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热销推荐

CNY 1,999.00

CNY 2,700.00


货期*
2周

规格
    • 100 ul

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经常一起买 (2)
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Specifications

Product Data
Applications ICC/IF, IHC, IP, WB
Recommend Dilution WB 1:500 - 1:2000;IF 1:50- 1:200;IP 1:20- 1:100
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen A synthetic peptide of human CHUK
Formulation Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration lot specific
Purification Affinity purification
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name conserved helix-loop-helix ubiquitous kinase
Background The NF-?B/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory I?B proteins. Most agents that activate NF-?B do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of I?B. The key regulatory step in this pathway involves activation of a high molecular weight I?B kinase (IKK) complex whose catalysis is generally carried out by three tightly associated IKK subunits.IKKa and IKKβ serve as the catalytic subunits of the kinase and IKK? serves as the regulatory subunit. Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKKβ (Ser176 and Ser180 in IKKa), which causes conformational changes, resulting in kinase activation.
Synonyms IKBKA; IKK-alpha; IKK1; IKKA; NFKBIKA; TCF16
Reference Data
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Acute myeloid leukemia, Adipocytokine signaling pathway, Apoptosis, B cell receptor signaling pathway, Chemokine signaling pathway, Chronic myeloid leukemia, Cytosolic DNA-sensing pathway, Epithelial cell signaling in Helicobacter pylori infection, MAPK signaling pathway, NOD-like receptor signaling pathway, Pancreatic cancer, Pathways in cancer, Prostate cancer, RIG-I-like receptor signaling pathway, Small cell lung cancer, T cell receptor signaling pathway, Toll-like receptor signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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