SynCAM (CADM1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500-1:2000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human CADM1
Formulation	Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	cell adhesion molecule 1
Database Link	NP_055148 Entrez Gene 54725 MouseEntrez Gene 363058 RatEntrez Gene 23705 Human UniProt ID Q9BY67
Background	Homologous to the poliovirus receptor (PVR/CD155), the Nectin immunoglobulin superfamily comprises four known isoforms, Nectin 1, 2, 3 and 4 (also designated TSLC1). TSLC1 is encoded by a tumor-suppressor gene in human non-small-cell lung cancer mapping to chromosome 11q23.2. The TSLC1 protein is an N-linked membrane glycoprotein that co-localizes with the Actin filament-binding protein, afadin, at cadherin-based adherens junctions in MDCKII epithelial cells. TSLC1 also interacts with the tumor-suppressor gene product DAL-1 (for differentially expressed in adenocarcinoma of the lung protein 1) to target Actin rearragement and cellular motility. TSLC1 may also form homodimers that function in homophilic, intracellular adhesion. TSLC1 expression is reduced or absent in a number of characterized cancer cell lines including A549. In prostate and breast cancer, as well as in pancreatic ductal adenocarcinoma, the TSLC1 promoter is commonly silenced by hypermethylation. Unlike other Nectins, which are more widely expressed, TSLC1 is mainly expressed in the placenta.
Synonyms	BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175; sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1
Reference Data
Protein Families	Transmembrane
Protein Pathways	Cell adhesion molecules (CAMs)

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