CTNND1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB 1:500 - 1:2000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human CTNND1
Formulation	Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	catenin delta 1
Database Link	NP_001078927 Entrez Gene 12388 MouseEntrez Gene 311163 RatEntrez Gene 1500 Human UniProt ID O60716
Background	Catenin d-1 (p120 catenin) has an amino-terminal coiled-coil domain followed by a regulatory domain containing multiple phosphorylation sites and a central Armadillo repeat domain of ten linked 42-amino acid repeats. The carboxy-terminal tail has no known function . Catenin d-1 fulfills critical roles in the regulation of cell-cell adhesion as it regulates E-cadherin turnover at the cell surface to determine the level of E-cadherin available for cell-cell adhesion . Catenin d-1 has both positive and negative effects on cadherin-mediated adhesion . Actin dynamics are also regulated by catenin d-1, which modulates RhoA, Rac, and cdc42 proteins . Analogous to β-catenin, catenin d-1 translocates to the nucleus, although its role at this location is unclear. Many studies show that catenin d-1 is expressed irregularly or is absent in various types of tumor cells, suggesting that catenin d-1 may function as a tumor suppressor . Phosphorylation of Tyr904 on Catenin-d-1 was identified at Cell Signaling Technology (CST) using PhosphoScan®, a CST's LC-MS/MS platform for phosphorylation site discovery .
Synonyms	CAS; CTNND; p120; p120(CAS); p120(CTN); P120CAS; P120CTN
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Adherens junction, Leukocyte transendothelial migration

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