RAGE (AGER) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500-1:2000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human AGER
Formulation	Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	advanced glycosylation end product-specific receptor
Database Link	NP_001127 Entrez Gene 11596 MouseEntrez Gene 81722 RatEntrez Gene 177 Human UniProt ID Q15109
Background	The receptor for advanced glycation end products (RAGE) is member of the immunoglobulin (Ig) superfamily. It can be expressed as full-length, membrane-bound RAGE isoform 1 or as a secreted sRAGE protein that lacks a transmembrane domain. RAGE is detected during early developmental stages and in the lung under normal physiological conditions and is upregulated at sites of inflammation. Advanced glycation end products (AGEs) and a variety of other ligands interact with this receptor. Ligand binding activates full-length RAGE and initiates downstream signaling pathways that include activation of NF-¦ÊB, which leads to production of pro-inflammatory cytokines and inflammation. Activation of these pathways has been implicated in various disease states including Alzheimer disease, diabetes, arthritis, and atherosclerosis. Soluble RAGE can competitively bind RAGE ligands in the extracellular environment, which prevents ligand interaction with full-length RAGE at the cell surface.
Synonyms	RAGE
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane

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