Profilin 1 (PFN1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500-1:2000
Reactivity	Human, Mouse, Rat, Monkey
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human PFN1
Formulation	Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	profilin 1
Database Link	NP_005013 Entrez Gene 18643 MouseEntrez Gene 64303 RatEntrez Gene 710753 MonkeyEntrez Gene 5216 Human UniProt ID P07737
Background	The dynamic polymerization and depolymerization of actin filaments, a process governed by external and internal signaling events, is vital for cell motility (immune cell function, migration, invasion, metastasis, angiogenesis), cell division and adhesion. Among the many regulators of actin dynamics are profilins. Profilins are conserved actin binding proteins that affect the rate of actin polymerization by binding actin monomers and promoting the exchange of ADP for ATP . Profilins bind to proteins involved in the regulation of actin dynamics including palladin, dynamin-1, VASP and N-WASP. In mice, knockout of the ubiquitously expressed profilin-1 indicates that the protein is essential for embryonic development. Profilin-2 is primarily expressed in brain and functions in the regulation of neurite outgrowth , membrane trafficking and endocytosis. The recently cloned profilin-3 is expressed in kidney and testes.
Synonyms	ALS18
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency
Protein Pathways	Regulation of actin cytoskeleton

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