BCL10 Rabbit Polyclonal Antibody
CAT#: TA326930
BCL10 Rabbit Polyclonal Antibody
Need it in bulk or conjugated?
Get a free quote
热销推荐
CNY 2,700.00
货期*
2周
规格
Product images
![](https://cdn.origene.com/img/defaults-img.jpg)
经常一起买 (2)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
CNY 300.00
CNY 1,430.00
Specifications
Product Data | |
Applications | WB |
Recommend Dilution | WB 1:500 - 1:2000 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Recombinant protein of human BCL10 |
Formulation | Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
Concentration | lot specific |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | B-cell CLL/lymphoma 10 |
Database Link | |
Background | Bcl10/CIPER/CLAP/mE10 is a widely expressed CARD (caspase recruitment domain) containing protein shown to induce apoptosis and activate NF-?B. The CARD domain mediates self-oligomerization, interactions with other CARD proteins and is necessary for NF-?B activation, although the precise mechanism which Bcl10 regulates these processes is not fully understood. The discovery of Bcl10 came from observations of the chromosomal translocation t(1;14)(p22;q32) from B cell lymphomas of the mucosa-associated lymphoid tissue (MALT). This translocation results in deregulated expression of a truncated form of Bcl10 which lacks apoptotic activity and enhances transformation. Studies from Bcl10 deficient mice demonstrate that Bcl10 is essential for the activation of NF-?B by T- and B-cell receptors. One third of Bcl10 deficient mice developed lethal exencephaly. Surviving mice were unaffected by various apoptotic stimuli, but were severely immunodeficient and defective in antigen receptor-induced NF-?Bactiviation. PKC or T-cell receptor signaling results in a downregulation of Bcl10 protein levels, attenuating both NF-?B activation and cellular proliferation and also provides a negative feedback regulation of the NF-?B signaling to T cell signaling. |
Synonyms | c-E10; CARMEN; CIPER; CLAP; IMD37; mE10 |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | B cell receptor signaling pathway, T cell receptor signaling pathway |
Documents
Product Manuals |
FAQs |
SDS |
Resources
抗体相关资料 |
Customer
Reviews
Loading...