BCL10 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 1:500 - 1:2000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human BCL10
Formulation	Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	B-cell CLL/lymphoma 10
Database Link	NP_003912 Entrez Gene 12042 MouseEntrez Gene 83477 RatEntrez Gene 8915 Human UniProt ID O95999
Background	Bcl10/CIPER/CLAP/mE10 is a widely expressed CARD (caspase recruitment domain) containing protein shown to induce apoptosis and activate NF-?B. The CARD domain mediates self-oligomerization, interactions with other CARD proteins and is necessary for NF-?B activation, although the precise mechanism which Bcl10 regulates these processes is not fully understood. The discovery of Bcl10 came from observations of the chromosomal translocation t(1;14)(p22;q32) from B cell lymphomas of the mucosa-associated lymphoid tissue (MALT). This translocation results in deregulated expression of a truncated form of Bcl10 which lacks apoptotic activity and enhances transformation. Studies from Bcl10 deficient mice demonstrate that Bcl10 is essential for the activation of NF-?B by T- and B-cell receptors. One third of Bcl10 deficient mice developed lethal exencephaly. Surviving mice were unaffected by various apoptotic stimuli, but were severely immunodeficient and defective in antigen receptor-induced NF-?Bactiviation. PKC or T-cell receptor signaling results in a downregulation of Bcl10 protein levels, attenuating both NF-?B activation and cellular proliferation and also provides a negative feedback regulation of the NF-?B signaling to T cell signaling.
Synonyms	c-E10; CARMEN; CIPER; CLAP; IMD37; mE10
Reference Data
Protein Families	Druggable Genome
Protein Pathways	B cell receptor signaling pathway, T cell receptor signaling pathway

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