PSME3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 1:500 - 1:2000
Reactivity	Human, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human PSME3
Formulation	Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	30 kDa
Gene Name	proteasome activator subunit 3
Database Link	NP_005780 Entrez Gene 287716 RatEntrez Gene 10197 Human UniProt ID P61289
Background	The 20S proteasome is the major proteolytic enzyme complex involved in intracellular protein degradation. PA700, PA28, and PA200 are three major protein complexes that function as activators of the 20S proteasome. There are three evolutionarily conserved subunits of PA28: PA28a (PSME1), PA28β (PSME2), and PA28? (PSME3) . PA28a and PA28β form a heteroheptameric complex and function by binding to the 20S complex at its opening site(s). The PA28a/β complex is present throughout the cell and participates in MHC class I antigen presentation by promoting the generation of antigenic peptides from foreign proteins. PA28? exists in the form of a homoheptamer and is mainly located in the nucleus. The PA28? complex exerts its function by binding and guiding specific nuclear target proteins to the 20S proteasome for further degradation.
Synonyms	HEL-S-283; Ki; PA28-gamma; PA28G; PA28gamma; REG-GAMMA
Reference Data
Protein Families	Stem cell - Pluripotency
Protein Pathways	Antigen processing and presentation, Proteasome

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