KDM1B Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	KDM1B antibody was raised against a 17 amino acid peptide near the amino terminus of human KDM1B.
Formulation	KDM1B antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	KDM1B antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 65 kDa; Observed: 68 kDa
Gene Name	lysine demethylase 1B
Database Link	NP_694587 Entrez Gene 218214 MouseEntrez Gene 221656 Human UniProt ID Q8NB78
Background	Flavin-dependent histone demethylases regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (reviewed in 1). KDM1B is a recently identified histone H3K4 demethylase that is required to establish maternal genomic imprints; targeted disruption of the KDM1B gene in mice led to lethality in their embryos, suggesting demethylation of H3K4 is critical for establishing the DNA methylation imprints (2). KDM1B has also been shown to play a role in the transcription elongation in several genes (3).
Synonyms	AOF1; bA204B7.3; C6orf193; dJ298J15.2; LSD2
Reference Data
Protein Families	Druggable Genome

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