FLI1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 0.5 - 1 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	FLI1 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human FLI1. The immunogen is located within the last 50 amino acids of FLI1 .
Formulation	FLI1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	FLI1 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 50 kDa; Observed: 52 kDa
Gene Name	Fli-1 proto-oncogene, ETS transcription factor
Database Link	NP_002008 Entrez Gene 14247 MouseEntrez Gene 315532 RatEntrez Gene 2313 Human UniProt ID Q01543
Background	The Friend leukemia virus integration 1 (FLI1) protein is a transcription factor containing an ETS DNA-binding domain and is highly expressed in hematopoietic cell lineages and vascular endothelial cells (1). FLI1 plays important roles in megakaryocytic differentiation (2) and vascular homeostasis (3). The FLI1 gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. (4). Abnormal expression of FLI1 can be used as an adverse prognostic indicator for acute myeloid leukemia (5).
Synonyms	EWSR2; SIC-1
Reference Data
Protein Families	Transcription Factors

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