DOPA Decarboxylase (DDC) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	DDC antibody was raised against a 14 amino acid peptide near the carboxy terminus of human DDC
Formulation	DDC Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	DDC Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 53 kDa; Observed: 50 kDa
Gene Name	dopa decarboxylase
Database Link	NP_000781 Entrez Gene 13195 MouseEntrez Gene 24311 RatEntrez Gene 1644 Human UniProt ID P20711
Background	DOPA decarboxylase (DDC) belongs to the group II decarboxylase family of proteins (1). It is an important protein in the catecholamine biosynthesis pathway. DDC catalyzes the second reaction in the biosynthesis of catecholamines, trace amines and serotonin (1,2). It can form a homodimer and is expressed in the central nervous system (2). DDC can be used as markers for dopaminergic, noradrenergic and serotonergic neurons in a variety of applications including depression, schizophrenia, Parkinson's disease, neuroendocrine tumors and drug abuse (3,4). Defects in DDC gene may cause the autosomal recessive disorder AADC deficiency (4).
Synonyms	AADC
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Histidine metabolism, Metabolic pathways, Phenylalanine metabolism, Tryptophan metabolism, Tyrosine metabolism

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