Apolipoprotein E (APOE) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	APO-E antibody was raised against a 19 amino acid peptide near the carboxy terminus of human APO-E.
Formulation	APO-E Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	APO-E Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 35 kDa; Observed: 34 kDa
Gene Name	apolipoprotein E
Database Link	NP_000032 Entrez Gene 11816 MouseEntrez Gene 25728 RatEntrez Gene 348 Human UniProt ID P02649
Background	APO-E Antibody: Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E (APO-E), a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Defects in APO-E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
Synonyms	AD2; APO-E; LDLCQ5; LPG
Reference Data
Protein Families	Adult stem cells, Druggable Genome, Secreted Protein, Stem cell - Pluripotency
Protein Pathways	Alzheimer's disease

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