p95 NBS1 (NBN) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 ug/mL, ICC: 2.5 ug/mL
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	NIBRIN antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human NIBRIN.
Formulation	NIBRIN Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	NIBRIN Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	nibrin
Database Link	NP_002476 Entrez Gene 27354 MouseEntrez Gene 4683 Human UniProt ID O60934
Background	NIBRIN Antibody: NIBRIN (NBN) is a member of the double-strand break repair complex MRE11/RAD50/NBN (MRN) which is involved in DNA double-strand break repair, DNA damage-induced checkpoint activation and plays a critical role in the maintenance of chromosome integrity. NIBRIN contains two modules found in cell cycle checkpoint proteins, a forkhead-associated domain adjacent to a breast cancer carboxy-terminal domain. Mutations in this gene are associated with Nijmegen breakage syndrome and maybe the cause of cancer predisposition and aplastic anemia.
Synonyms	AT-V1; AT-V2; ATV; NBS; NBS1; P95
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Homologous recombination

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