Gabbr2 Mouse Monoclonal Antibody [Clone ID: S81-2]

CAT#: TA326531

Mouse Monoclonal Anti-GABA-B Receptor 2 Antibody



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CNY 5,830.00


货期*
4周

规格
    • 100 ug

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Specifications

Product Data
Clone Name S81-2
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Immunogen Fusion protein amino acids 861-912 of rat GABA(B)R2
Formulation PBS pH7.4, 50% glycerol
Concentration lot specific
Purification Protein G Purified
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name gamma-aminobutyric acid type B receptor subunit 2
Background GABA (-aminobutyric acid) is the primary inhibitory neurotransmitter in the central nervous system and interacts with three different receptors: GABA(A), GABA(B) and GABA(C) receptor. The ionotropic GABA(A) and GABA(C) receptors are ligand-gated ion channels that produce fast inhibitory synaptic transmission. In contrast, the metabotropic GABA(B) receptor is coupled to G proteins that modulate slow inhibitory synaptic transmission . Functional GABA(B) receptors form heterodimers of GABA(B)R1 and GABA(B)R2 where GABA(B)R1 binds the ligand and GABA(B)R2 is the primary G protein contact site . Two isoforms of GABA(B)R1 have been cloned: GABA(B)R1a is a 130 kD protein and GABA(B)R1b is a 95 kD protein . G proteins subsequently inhibit adenyl cylase activity and modulate inositol phospholipid hydrolysis. GABA(B) receptors have both pre- and postsynaptic inhibitions: presynaptic GABA(B) receptors inhibit neurotransmitter release through suppression of high threshold calcium channels, while postsynaptic GABA(B) receptors inhibit through coupled activation of inwardly rectifying potassium channels. In addition to synaptic inhibition,GABA(B) receptors may also be involved in hippocampal long-term potentiation, slow wave sleep and muscle relaxation .
Synonyms FLJ36928; GABA-B-R2; GABABR2; Gb2; GPR51; GPRC3B; HG20; HRIHFB2099
Note Detects ~105kDa. No cross-reactivity against GABA(B)R1
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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