Gabbr2 Mouse Monoclonal Antibody [Clone ID: S81-2]
CAT#: TA326531
Mouse Monoclonal Anti-GABA-B Receptor 2 Antibody
Need it in bulk or conjugated?
Get a free quote
CNY 5,830.00
货期*
4周
规格
Product images
经常一起买 (1)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
CNY 300.00
CNY 1,430.00
Specifications
Product Data | |
Clone Name | S81-2 |
Reactivity | Human, Mouse, Rat |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Fusion protein amino acids 861-912 of rat GABA(B)R2 |
Formulation | PBS pH7.4, 50% glycerol |
Concentration | lot specific |
Purification | Protein G Purified |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | gamma-aminobutyric acid type B receptor subunit 2 |
Database Link | |
Background | GABA (-aminobutyric acid) is the primary inhibitory neurotransmitter in the central nervous system and interacts with three different receptors: GABA(A), GABA(B) and GABA(C) receptor. The ionotropic GABA(A) and GABA(C) receptors are ligand-gated ion channels that produce fast inhibitory synaptic transmission. In contrast, the metabotropic GABA(B) receptor is coupled to G proteins that modulate slow inhibitory synaptic transmission . Functional GABA(B) receptors form heterodimers of GABA(B)R1 and GABA(B)R2 where GABA(B)R1 binds the ligand and GABA(B)R2 is the primary G protein contact site . Two isoforms of GABA(B)R1 have been cloned: GABA(B)R1a is a 130 kD protein and GABA(B)R1b is a 95 kD protein . G proteins subsequently inhibit adenyl cylase activity and modulate inositol phospholipid hydrolysis. GABA(B) receptors have both pre- and postsynaptic inhibitions: presynaptic GABA(B) receptors inhibit neurotransmitter release through suppression of high threshold calcium channels, while postsynaptic GABA(B) receptors inhibit through coupled activation of inwardly rectifying potassium channels. In addition to synaptic inhibition,GABA(B) receptors may also be involved in hippocampal long-term potentiation, slow wave sleep and muscle relaxation . |
Synonyms | FLJ36928; GABA-B-R2; GABABR2; Gb2; GPR51; GPRC3B; HG20; HRIHFB2099 |
Note | Detects ~105kDa. No cross-reactivity against GABA(B)R1 |
Reference Data |
Documents
Product Manuals |
FAQs |
SDS |
Resources
抗体相关资料 |
Customer
Reviews
Loading...