Clcn3 Mouse Monoclonal Antibody [Clone ID: S258-5]

Specifications

Product Data
Clone Name	S258-5
Recommend Dilution	WB: 1ug/ml, IHC: 0.1-1ug/ml, IF: 1-10ug/ml
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Synthetic peptide amino acids 98-115 (cytoplasmic N-terminus) of rat Clcn3
Formulation	PBS pH7.4, 50% glycerol
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	chloride voltage-gated channel 3
Database Link	NP_445815 Entrez Gene 1182 HumanEntrez Gene 12725 MouseEntrez Gene 84360 Rat UniProt ID P51792
Background	Clcn3 mediates the exchange of chloride ions against protons, and functions as an antiporter and contributesto the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking andexocytosis. It may play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could also help neuronal cells to establish short-term memory.
Synonyms	ClC-3; CLC3
Note	Detects ~90kDa. Does not cross-react with Clcn4 or Clcn5 (based on KO validation results)
Reference Data

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