Bcan Mouse Monoclonal Antibody [Clone ID: S294A-6]

Specifications

Product Data
Clone Name	S294A-6
Recommend Dilution	WB: 1:1000
Reactivity	Rat, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Fusion protein amino acids 219-655 of rat Brevican
Formulation	PBS pH7.4, 50% glycerol
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	brevican
Database Link	NP_001028837 Entrez Gene 12032 MouseEntrez Gene 25393 Rat UniProt ID P55068
Background	Brevican is the most abundant chondroitin sulfate proteoglycan in the extracellular matrix of the adultbrain. It is a member of the lectican family of aggregating extracellular matrix proteoglycans that bearchondroitin sulfate (CS) chains. It is highly expressed in the central nervous system and is thought to stabilize synapses and inhibit neural plasticity. Brevican is secreted from astrocytes and neurons as a 145 kD core protein that bears up to three, covalently-linked, CS chains. It is also is secreted as a 145 kD core protein without CS chains. When cleaved by extracellular glutamyl endopeptidases, the ADAMTSs, a 55 kD Nterminal fragment is formed that contains the unique Cterminal epitope EAMESE.
Synonyms	BEHAB; brevican; CSPG7; MGC13038
Note	Detects ~140kDa (and smaller due to proteolytic cleavage)
Reference Data

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