Abcc8 Mouse Monoclonal Antibody [Clone ID: S289-16]

Specifications

Product Data
Clone Name	S289-16
Recommend Dilution	WB: 1ug/ml, IHC: 0.1-1ug/ml, IF: 1-10ug/ml
Reactivity	Mouse, Hamster, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Fusion protein amino acids 1548-1582 (cytoplasmic C-terminus) of rat SUR1
Formulation	PBS pH7.4, 50% glycerol
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	ATP binding cassette subfamily C member 8
Database Link	NP_037171 Entrez Gene 20927 MouseEntrez Gene 25559 Rat UniProt ID Q09429
Background	Sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea classof antidiabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. Morespecifically, SUR proteins are subunits of the inward rectifier potassium ion channels Kir6.x (6.1 and 6.2) .The association of four Kir6.x and four SUR subunits form an ion conducting channel commonly referred to as theKATP channel.The primary function of the sulfonylurea receptor is to sense intracellular levels of the nucleotides ATP and ADPand in response facilitate the open or closing its associated Kir6.x potassium channel. Hence the KATP channel monitors the energy balance within the cell .
Synonyms	ABC36; HHF1; HI; HRINS; MRP8; PHHI; SUR; SUR1; TNDM2
Note	Detects ~160kDa. Does not cross-react with SUR2B
Reference Data

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