Abcc9 Mouse Monoclonal Antibody [Clone ID: S319A-14]

Specifications

Product Data
Clone Name	S319A-14
Reactivity	Rat, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Fusion protein amino acids 1505-1546 (SSIVDAGLVLVFSEGILVECDTGPNLLQH KNGLFSTLVMTNK, cytoplasmic C-terminus) of mouse SUR2A
Formulation	PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Database Link	NP_001038185 Entrez Gene 25560 RatEntrez Gene 20928 Mouse UniProt ID P70170
Background	Sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of antidiabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specifically, SUR proteins are subunits of the inwardrectifier potassium ion channels Kir6.x (6.1 and 6.2) . The association of four Kir6.x and four SUR subunits form an ion conducting channel commonly referred to as the KATP channel.The primary function of the sulfonylurea receptor is to sense intracellular levels of the nucleotides ATP and ADP and in response facilitate the open or closing its associated Kir6.x potassium channel. Hence the KATP channel monitors the energy balance within the cell .
Synonyms	ABC37; CMD1O; FLJ36852; SUR2
Note	Detects ~120kDa. Does not cross-react with SUR2B
Reference Data

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