TNFRSF1A Rabbit Polyclonal Antibody

Specifications

Product Data
Recommend Dilution	WB: 1:1000
Reactivity	Human, Mouse, Rat, Monkey, Bovine, Canine, Rabbit
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide corresponding to AA 20-43 of the mouse TNF-R1 sequence, identical to rat and human over those residues
Formulation	PBS pH 7.4; 50% glycerol, 0.09% azide.
Concentration	lot specific
Purification	Peptide Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	tumor necrosis factor receptor superfamily member 1A
Database Link	NP_001056 Entrez Gene 21937 MouseEntrez Gene 25625 RatEntrez Gene 722033 MonkeyEntrez Gene 7132 Human UniProt ID P19438
Background	The Tumor Necrosis Factor Receptor (TNFR) also known as Cluster of differentiation (CD120) is a protein that belongs to the (TNF)/ (TNFR) superfamily. TNF interacts with two distinct receptors TNFR1 and TNFR2. These receptors share no homology on their cytoplasmic sequences.TNFR1 also known as p55/p60 is a high affinity receptor for TNF-. The TNFR1 has an extracellular domain with variable numbers of cysteine-rich repeats. The functional properties of TNFR1 are targets in new therapies for osteoporosis, chronic inflammatory and autoimmune diseases . The TNF-/TNFR1 receptor complex is responsible for the recruitment and the subsequent activation of the caspase (aspartate-specific cysteine proteases) that regulate apoptosis.
Synonyms	CD120a; FPF; MS5; p55; p55-R; p60; TBP1; TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55
Note	Identifies a band ~55kD on WB
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transcription Factors, Transmembrane
Protein Pathways	Adipocytokine signaling pathway, Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Cytokine-cytokine receptor interaction, MAPK signaling pathway

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