Piccolo (PCLO) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1:1000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Full length protein
Formulation	PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	piccolo presynaptic cytomatrix protein
Database Link	NP_055325 Entrez Gene 26875 MouseEntrez Gene 56768 RatEntrez Gene 27445 Human UniProt ID Q9Y6V0
Background	Piccolo, also referred to as Aczonin, is a large protein which consists of an N-terminal Zn2+ finger, several piccolo-bassoon homology domains and C-terminal PDZ and C2 domains . In general it is found together with bassoon, a related huge multi-domain protein of the CAZ (cytoskeletal matric assembled at active zones) . Piccolo is a scaffolding protein for proteins involved in endo- and exocytosis of synaptic vesicles. Piccolo has also been shown to interfere with clathrin medicated endocytosis by binding to the F-actin and dynamin binding protein Abp1 .
Synonyms	ACZ
Note	Detects ~550kDa corresponding to the molecular weight of Picollo. Multiple isoforms can be detected. No cross-reactivity to Bassoon.
Reference Data

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