Hsp105 (HSPH1) Rabbit Polyclonal Antibody [Clone ID: N/A]

Specifications

Product Data
Clone Name	N/A
Applications	WB
Recommend Dilution	WB: 1:1000
Reactivity	Human, Monkey, Hamster, Rat, Mouse, Sheep, Yeast, Cow
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide derived from the sequence of hamster Hsp110; sequence identical to human and mouse
Formulation	PBS pH7.2, 50% glycerol, 0.09% sodium azide
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	heat shock protein family H (Hsp110) member 1
Database Link	NP_006635 Entrez Gene 15505 MouseEntrez Gene 288444 RatEntrez Gene 721956 MonkeyEntrez Gene 10808 Human UniProt ID Q92598
Background	Hsp110 belongs to a family of large stress proteins known as the Hsp110/SSE Family. The proteins in this family are the most distantly known relatives of the well studied Hsp70 family. They share 30-33% amino acid identity, mostly in the conserved ATP-binding domain . Hsp110 cooperates with Hsp70 in protein folding in the eukaryotic cytosol . In mammals, Hsp110 is constitutively expressed, but exhibits particularly high levels in the brain. Both Hsp70 and Hsp110 are elevated after cerebral ischemia. Recent studies demonstrate that the protective effects of Hsp110 deficiency in cerebral ischemia may partly be mediated by an increase in the chaperone activity of Hsp70 . Studies also suggest that Hsp110 can be used in heat shock protein-based cancer immunotherapy .
Synonyms	HSP105; HSP105A; HSP105B; NY-CO-25
Note	Detects ~110kDa
Reference Data
Protein Families	Stem cell - Pluripotency

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