Carbonic Anhydrase I (CA1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 200-1000 WB positive control: Human lung cancer tissue
Reactivity	Human, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Full length fusion protein
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	29 kDa
Gene Name	carbonic anhydrase 1
Database Link	NP_001122301 Entrez Gene 759 Human UniProt ID P00915
Background	Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes; including respiration; calcification; acid-base balance; bone resorption; and the formation of aqueous humor; cerebrospinal fluid; saliva; and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA1 is closely linked to CA2 and CA3 genes on chromosome 8; and it encodes a cytosolic protein which is found at the highest level in erythrocytes. Variants of this gene have been described in some populations. Multiple alternatively spliced variants; encoding the same protein; have been identified. Transcript variants of CA1 utilizing alternative polyA_sites have been described in literature.
Synonyms	CA-I; CAB; Car1; HEL-S-11
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Nitrogen metabolism

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