Cyclin A1 (CCNA1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: 293T cell lysate IHC: 50-100 Positive control: Human breast cancer Predicted cell location: Nucleus
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to C terminal 300 amino acids of human cyclin A1
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	52 kDa
Gene Name	cyclin A1
Database Link	NP_001104515 Entrez Gene 12427 MouseEntrez Gene 295052 RatEntrez Gene 8900 Human UniProt ID P78396
Background	The protein encoded by this gene belongs to the highly conserved cyclin family; whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain; as well as in several leukemic cell lines; and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases; which give two distinct kinase activities; one appearing in S phase; the other in G2; and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators; such as Rb family proteins; transcription factor E2F-1; and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms	CT146
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Acute myeloid leukemia, Cell cycle, Pathways in cancer, Progesterone-mediated oocyte maturation

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