Tyrosine Hydroxylase (TH) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 15-50 Positive control: Human ovarian cancer Predicted cell location: Cytoplasm
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 503-517 amino acids of human tyrosine hydroxylase
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	tyrosine hydroxylase
Database Link	NP_000351 Entrez Gene 7054 Human UniProt ID P07101
Background	The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines; hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Synonyms	DYT5b; DYT14; TYH
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Metabolic pathways, Parkinson's disease, Tyrosine metabolism

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