Tyrosinase (TYR) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: A375, Hela and Jurkat cells IHC: 25-100 Positive control: Human thyroid cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 19-319 amino acids of human tyrosinase
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	60 kDa
Gene Name	tyrosinase
Database Link	NP_000363 Entrez Gene 22173 MouseEntrez Gene 7299 Human UniProt ID P14679
Background	The enzyme encoded by this gene catalyzes the first 2 steps; and at least 1 subsequent step; in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities; and requires copper for function. Mutations in this gene result in oculocutaneous albinism; and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene.
Synonyms	ATN; CMM8; OCA1; OCA1A; OCAIA; SHEP3
Reference Data
Protein Families	Transmembrane
Protein Pathways	Melanogenesis, Metabolic pathways, Riboflavin metabolism, Tyrosine metabolism

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