G protein alpha S (GNAS) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 200-1000 WB positive control: Mouse brain tissue IHC: 25-100 Positive control: Human liver cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to C terminal 200 amino acids of human GNAS complex locus
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	46 kDa
Gene Name	GNAS complex locus
Database Link	NP_000507 Entrez Gene 14683 MouseEntrez Gene 24896 RatEntrez Gene 2778 Human UniProt ID P84996
Background	This locus has a highly complex imprinted expression pattern. It gives rise to maternally; paternally; and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons; and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus; and the antisense transcript; are paternally expressed noncoding RNAs; and may regulate imprinting in this region. In addition; one of the transcripts contains a second overlapping ORF; which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed; which results in different forms of the stimulatory G-protein alpha subunit; a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a; pseudohypoparathyroidism type 1b; Albright hereditary osteodystrophy; pseudopseudohypoparathyroidism; McCune-Albright syndrome; progressive osseus heteroplasia; polyostotic fibrous dysplasia of bone; and some pituitary tumors.?
Synonyms	AHO; C20orf45; GNAS1; GPSA; GSA; GSP; NESP; PHP1A; PHP1B; PHP1C; POH; SgVI
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Calcium signaling pathway, Dilated cardiomyopathy, Gap junction, GnRH signaling pathway, Long-term depression, Melanogenesis, Taste transduction, Vascular smooth muscle contraction, Vibrio cholerae infection

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