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ACTH (POMC) Rabbit Polyclonal Antibody
CAT＃: TA323526S
Anti-POMC Rabbit Polyclonal Antibody
Size: 100 ul
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CNY 800.00
CNY 1,280.00
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CNY 300.00
CNY 1,430.00
CNY 3,080.00
Specifications
| Product Data | |
| Applications | IHC, WB |
| Recommend Dilution | WB: 1000-5000 WB positive control: Human liver cancer tissue IHC: 25-100 Positive control: Human breast cancer Predicted cell location: Cytoplasm |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide corresponding to a region derived from 255-267 amino acids of Human proopiomelanocortin |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Predicted Protein Size | 29 kDa |
| Gene Name | proopiomelanocortin |
| Database Link | |
| Background | This gene encodes a polypeptide hormone precursor that undergoes extensive; tissue-specific; post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and; depending on tissue type and the available convertases; processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin; essential for normal steroidogenesis and the maintenance of normal adrenal weight; and lipotropin beta are the major end products. In other tissues; including the hypothalamus; placenta; and epithelium; all cleavage sites may be used; giving rise to peptides with roles in pain and energy homeostasis; melanocyte stimulation; and immune modulation. These include several distinct melanotropins; lipotropins; and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity; adrenal insufficiency; and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.? |
| Synonyms | ACTH; CLIP; LPH; MSH; NPP; POC |
| Reference Data | |
| Protein Families | Druggable Genome |
| Protein Pathways | Adipocytokine signaling pathway, Melanogenesis |
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