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ACTH (POMC) Rabbit Polyclonal Antibody
CAT＃: TA323524S
Anti-POMC Rabbit Polyclonal Antibody
Size: 100 ul
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CNY 800.00
CNY 1,280.00
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CNY 300.00
CNY 1,430.00
CNY 3,080.00
Specifications
| Product Data | |
| Applications | IHC, WB |
| Recommend Dilution | WB: 500-2000 WB positive control: Mouse liver tissue and Mouse skeletal muscle tissue lysates IHC: 25-50 Positive control: Human colorectal cancer Predicted cell location: Secreted |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide corresponding to a region derived from 253-267 amino acids of human proopiomelanocortin |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Predicted Protein Size | 30 kDa |
| Gene Name | proopiomelanocortin |
| Database Link | |
| Background | This gene encodes a polypeptide hormone precursor that undergoes extensive; tissue-specific; post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and; depending on tissue type and the available convertases; processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin; essential for normal steroidogenesis and the maintenance of normal adrenal weight; and lipotropin beta are the major end products. In other tissues; including the hypothalamus; placenta; and epithelium; all cleavage sites may be used; giving rise to peptides with roles in pain and energy homeostasis; melanocyte stimulation; and immune modulation. |
| Synonyms | ACTH; CLIP; LPH; MSH; NPP; POC |
| Reference Data | |
| Protein Families | Druggable Genome |
| Protein Pathways | Adipocytokine signaling pathway, Melanogenesis |
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