ABCE1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 500-2000 WB positive control: NIH/3T3 cells and human ovarian cancer tissue
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 345-562 amino acids of human ATP-binding cassette, sub-family E (OABP), member 1
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	67 kDa
Gene Name	ATP binding cassette subfamily E member 1
Database Link	NP_001035809 Entrez Gene 24015 MouseEntrez Gene 6059 Human UniProt ID P61221
Background	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1; MDR/TAP; MRP; ALD; OABP; GCN20; White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor; this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system; the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene.
Synonyms	ABC38; OABP; RLI; RNASEL1; RNASELI; RNS4I
Reference Data
Protein Families	Druggable Genome

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