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CDK3 Rabbit Polyclonal Antibody
CAT＃: TA323198S
Anti-CDK3 Rabbit Polyclonal Antibody
Size: 100 ul
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CNY 800.00
CNY 1,280.00
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CNY 300.00
CNY 1,430.00
Specifications
| Product Data | |
| Applications | IHC |
| Recommend Dilution | IHC: 25-100 Positive control: Human lung cancer Predicted cell location: Cytoplasm |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide corresponding to a region derived from 235-250 amino acids of Human cyclin-dependent kinase 3 |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Gene Name | cyclin-dependent kinase 3 |
| Database Link | |
| Background | This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase; in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1; ATF1; RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities; and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1; E2F2 and E2F3 in a RB1-independent manner. |
| Synonyms | cyclin-dependent kinase 3 |
| Reference Data | |
| Protein Families | Druggable Genome, Protein Kinase |
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