ID4 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 20-100 Positive control: Human liver cancer Predicted cell location: Cytoplasm, Nucleus
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 19-38 amino acids of Human inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	inhibitor of DNA binding 4, HLH protein
Database Link	NP_001537 Entrez Gene 15904 MouseEntrez Gene 3400 Human UniProt ID P47928
Background	DNA-binding protein inhibitor ID-4?is a?protein?that in humans is encoded by the?ID4?gene. Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative (antimorph) HLH proteins encoded by Id-related genes; such as ID4; also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently; Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins .
Synonyms	bHLHb27; IDB4
Reference Data
Protein Families	ES Cell Differentiation/IPS, Transcription Factors
Protein Pathways	TGF-beta signaling pathway

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