Cathepsin E (CTSE) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Mouse stomach tissue IHC: 100-300 Positive control: Human ovarian cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 57-367 amino acids of Human Cathepsin E
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	43 kDa
Gene Name	cathepsin E
Database Link	NP_001901 Entrez Gene 13034 MouseEntrez Gene 25424 RatEntrez Gene 1510 Human UniProt ID P14091
Background	The protein encoded by this gene is a gastric aspartyl protease that functions as a disulfide-linked homodimer. This protease; which is a member of the peptidase C1 family; has a specificity similar to that of pepsin A and cathepsin D. It is an intracellular proteinase that does not appear to be involved in the digestion of dietary protein and is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach. It is the first aspartic proteinase expressed in the fetal stomach and is found in more than half of gastric cancers. It appears; therefore; to be an oncofetal antigen. Transcript variants utilizing alternative polyadenylation signals and two transcript variants encoding different isoforms exist for this gene.
Synonyms	CATE
Reference Data
Protein Families	Druggable Genome, Protease
Protein Pathways	Lysosome

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