PSMD8 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 50-200 Positive control: Human colon cancer Predicted cell location: Cytoplasm, Nucleus
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Full length fusion protein
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	proteasome 26S subunit, non-ATPase 8
Database Link	NP_002803 Entrez Gene 57296 MouseEntrez Gene 5714 Human UniProt ID P48556
Background	The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes; a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base; which contains 6 ATPase subunits and 2 non-ATPase subunits; and a lid; which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome; the immunoproteasome; is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1.
Synonyms	HEL-S-91n; HIP6; HYPF; Nin1p; p31; Rpn12; S14
Reference Data
Protein Pathways	Proteasome

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