RAB6A Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: 293T cells and mouse brain tissue, A549, Hela, A172 and HT-29 cells IHC: 25-100 Positive control: Human skin Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 125-139 amino acids of Human Ras-related protein Rab-6A
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	24 kDa
Gene Name	RAB6A, member RAS oncogene family
Database Link	NP_002860 Entrez Gene 19346 MouseEntrez Gene 84379 RatEntrez Gene 5870 Human UniProt ID P20340
Background	This gene encodes a member of the RAB family; which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus; which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1; which interacts with the HCMV virion tegument protein; pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms	RAB6
Reference Data
Protein Families	Druggable Genome

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