TIMP2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-100 Positive control: Human liver cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 30-220 amino acids of human TIMP metallopeptidase inhibitor 2
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	TIMP metallopeptidase inhibitor 2
Database Link	NP_003246 Entrez Gene 21858 MouseEntrez Gene 29543 RatEntrez Gene 7077 Human UniProt ID P16035
Background	This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases; a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases; the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result; the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors; and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
Synonyms	CSC-21K; DDC8
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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