14-3-3 beta (YWHAB) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Hela cells and mouse kidney tissue IHC: 25-100 Positive control: Human lung cancer Predicted cell location: Cytoplasm, Nucleus
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 72-87 amino acids of Human tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	28 kDa
Gene Name	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Database Link	NP_003395 Entrez Gene 54401 MouseEntrez Gene 56011 RatEntrez Gene 7529 Human UniProt ID P31946
Background	This gene encodes a protein belonging to the 14-3-3 family of proteins; members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases; suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants; which encode the same protein; have been identified for this gene.
Synonyms	GW128; HEL-S-1; HS1; KCIP-1; YWHAA
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Cell cycle, Neurotrophin signaling pathway, Oocyte meiosis

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